The Accel-NGS Adaptase Module constructs NGS libraries from bisulfite-converted DNA from single cells. The Adaptase Module maximizes the recovery of low concentrations of single stranded DNA and libraries consistently exhibit superior complexity with reduced composition bias to provide a more faithful representation of the methylome. Using the in-line barcoding option, cells can be mulitplexed to increase throughput and further reduce library prep costs.
The Adaptase Module can be used for many applications, such as cataloging cell populations within heterogeneous tissues, assessing normal tissue for regulation of cellular mechanisms (e.g., differentiation), gaining insight into epigenetic alterations in disease states, and exploring across species to identify evolutionary conservation of epigenomic regulation.
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The below solution is included with your Library Kit. If you require extra, please add now:
The Accel-NGS Adaptase Module requires commercially-available oligonucleotide primers, enzymes, and buffers (ordered separately) for complete functionality. Please see the Accel-NGS Adaptase Module for Single-Cell Methyl-Seq Library Preparation Protocol for a complete list of required third-party materials not supplied by Swift Biosciences.
For Customers Outside the United States: Please request a quote or select from our list of distributors.