The Accel-NGS Methyl-Seq DNA Library prep utilizes Adaptase® technology for capturing single-stranded DNA molecules in an unbiased manner. As bisulfite treatment of samples damages DNA, Swift Biosciences’ single-strand compatible Adaptase technology maximizes recovery of DNA from bisulfite-converted samples. The resultant libraries accurately represent sample base composition of the entire genome for the analyzed organism. The technology has quickly become the gold standard for providing the most comprehensive coverage of the methylome. It is an excellent choice for whole genome bisulfite sequencing as well as targeted bisulfite sequencing applications, such as RRBS and hybridization capture using the NimbleGen™ SeqCap™ Epi Enrichment Sysem. The Accel-NGS Methyl-Seq Kit is also compatible with bisulfite-converted DNA samples enriched by ChIP or other methods. This library preparation technology contains a uracil tolerant polymerase which is ideal for sequencing ancient DNA samples that may contain uracil nucleotides as a result of damage.