The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

What to expect after a year in space

Space is the final frontier for understanding how extreme environments affect human physiology. Following twin astronauts, one of which spent a year-long mission on the International Space Station, Garrett-Bakelman et al. examined molecular and physiological traits that may be affected by time in space (see the Perspective by Löbrich and Jeggo). more »

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Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation

Genome-wide association studies in obesity have identified a large number of non-coding loci located near genes expressed in the central nervous system. However, due to the difficulties in isolating and characterizing specific neuronal subpopulations, few obesity-associated single-nucleotide polymorphisms have been functionally characterized. more »

Towards optimized viral metagenomes for double-stranded and single-stranded DNA viruses from challenging soils

Soils impact global carbon cycling and their resident microbes are critical to their biogeochemical processing and ecosystem outputs. Based on studies in marine systems, viruses infecting soil microbes likely modulate host activities via mortality, horizontal gene transfer, and metabolic control. more »

Soil microbial responses to drought and exotic plants shift carbon metabolism

Significant gaps in our understanding of how global change drivers interact to affect the resistance and functioning of microbial communities hinders our ability to model ecosystem responses and feedbacks to co-occurring global stressors. more »

Unlocking a mechanism of lineage determination in the development of primary cancers using genomics.

Researchers are performing WGS and WES to identify immune cell cytokines that act on oncogenically transforming hepatocyctesand their epigenetic regulation.  more »

The highest peaking calling, sensitivity, and specificity values recorded for ChIP-Seq.

Seven methods designed for low input DNA/ChIP-seq sample preparation  (Accel-NGS 2S, Bowman-method, HTML-PCR, SeqPlex, DNA SMART, TELP, and ThruPLEX) were performed on five replicates of 1 ng and 0.1 ng input.  more »