Swift Hybridization Capture Kits

Our Kits Save Sequencing Costs by Targeting Only Genes of Interest

Swift Hybridization capture kitsSwift Hybridization Capture Kits, enable enrichment and sequencing of the human exome or subsets of disease-related genes involved in cancer and inherited diseases. Our kits save sequencing costs by targeting only genes of interest using a 4-hour capture, while delivering the breadth and depth of coverage required for comprehensive yet sensitive genomic profiling.

The high quality of Swift panels, combined with optimized hybridization reagents and protocols, results in a substantial improvement in on-target mapping rate and coverage uniformity compared to other commercially available panels. The panels are designed to allow variants to be called using fewer reads, and therefore, at lower costs.

These products include gene-specific capture probes and supporting hybridization and wash reagents, including beads and blockers. When used in conjunction with Swift’s portfolio of library preparation kits including library adapters with molecular identifiers, labs have a variety of complete workflow options to convert input DNA into targeted Illumina®-compatible libraries in a 1.5-day workflow.

Highlights

Enables enrichment of the human exome or subsets of disease-related genes

  • Superior on-target performance and comprehensive coverage of human coding sequences from the RefSeq database, probes designed to version hg19

Saves sequencing costs

  • Pre-capture multiplexing facilitates orders of magnitude more efficient next generation sequencing by targeting genes of interest while conserving enrichment reagents

Provides high quality data

  • Probes achieve deep and uniform coverage even across GC-rich regions such as first exons

The Exome Panel consists of 429,826 individually synthesized, and quality controlled Swift Probes. The Exome Research Panel spans a 39 Mb target region (19,396 genes) of the human genome and covers 51 Mb of end-to-end tiled probe space. All probes in the panel are manufactured using GMP standards. Mass spectrometry and OD measurements are taken for each probe to ensure appropriate representation of the correctly manufactured probes in the pool.

The Pan-Cancer Panel consists of 7816 Swift Probes, spanning 800 kb of the human genome, for the enrichment of 127 significantly mutated genes implicated across 12 tumor tissue types for deeper sequencing coverage.

The Inherited Diseases Panel enables deeper sequencing of genomic regions containing genes and SNPs associated with inherited diseases. The gene list is based on the HGMD® (Human Gene Mutation Database) repository of known inherited disease-causing mutations.

Swift Hybridization Panel Specs

Sample Types and Applications

  • Detection of germline inherited SNVs and Indels
  • Low frequency somatic variant detection of SNVs and Indels
  • Copy number variant detection

Compatible DNA Library Prep Kits

  • Swift 2S Turbo, for high quality genomic DNA and FFPE
  • Accel-NGS 2S Hyb for FFPE, cfDNA, and incorporation of molecular identifiers (MIDs) for ultra-low frequency variant detection
  • Accel-NGS 1S Plus for heavily nicked or denatured samples
  • Ligation-based library preparation kits from other vendors (not compatible with transposon-based kits)

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DATA SHEET
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PANEL-SPECIFIC BIOINFORMATICS FILES
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WORKFLOW
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PROTOCOL
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